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Allyx Therapeutics, Inc.

BiotechnologyBiotechnologyAlzheimer's DiseaseNeurodegenerative
📍 New Haven, CT, United States• Founded 2019
StreetZero Signal 80
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About Allyx Therapeutics, Inc.

Allyx Therapeutics, Inc. is a clinical-stage biotechnology company based in New Haven, Connecticut, developing novel therapies for Alzheimer’s disease and other neurodegenerative diseases. Its approach focuses on protecting synapses, the connections between neurons that support memory and cognitive function. The company’s lead candidate, ALX-001, is an oral small molecule designed to block harmful signaling associated with synapse loss while preserving normal glutamate signaling at mGluR5. It has in-licensed the mGluR5 program from Bristol Myers Squibb and Yale University and has leveraged non-dilutive grants from NIA, NIH, and other organizations.

LATEST FUNDINGPrivate Placement
$27.9M
Announced 2026-10-21
TOTAL RAISED$43.62M
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Key highlights

  • Raised $27.9M via private placement after earlier Series A and Series B rounds.
  • Lead asset ALX-001 is a first-in-class oral mGluR5 modulator for synapse protection in Alzheimer’s.
  • Secured nearly $12M in non-dilutive grants from NIH, NIA, Michael J. Fox Foundation and Alzheimer’s Association.
  • In-licensed mGluR5 program from Bristol Myers Squibb and Yale University in 2021.
  • Elm Street Ventures led Series A and holds a board seat.

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